Description

4-Chloro-6,8-Difluoroquinoline is a high-purity fluorinated quinoline derivative, a crucial advanced intermediate in modern synthetic chemistry. Its value lies in its unique halogenated structure, which serves as a versatile scaffold for constructing complex molecules with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel quinolone and fluoroquinolone-based drug candidates with potential antibacterial, anticancer, or antiviral properties.
• Agrochemical Research: Used in the discovery and development of new-generation pesticides and herbicides, where the difluoroquinoline core can enhance bioactivity and environmental stability.
• Material Science: Serves as a precursor for creating functionalized organic compounds used in electronic materials, liquid crystals, or organic light-emitting diodes (OLEDs).
• Chemical Synthesis: Acts as a versatile reagent in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce the quinoline moiety into more complex structures.
• Academic & R&D: Essential for medicinal chemistry programs and organic synthesis research in universities and contract research organizations (CROs).

Basic Information

Product Name	4-Chloro-6,8-Difluoroquinoline
CAS No.	239463-89-9
Molecular Formula	C9H4ClF2N
Molecular Weight	199.59 g/mol
Synonyms	4-Chloro-6,8-difluoroquinoline; 6,8-Difluoro-4-chloroquinoline; Quinoline, 4-chloro-6,8-difluoro-; 4-Chloro-6,8-difluorochinolin; 239463-89-9
EINECS	Contact for details

Quality Control

Our 4-Chloro-6,8-Difluoroquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.