Description

trans-2,3-Difluorocinnamic Acid is a high-purity fluorinated cinnamic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the precise positioning of fluorine atoms on the aromatic ring, which can significantly alter the electronic properties, metabolic stability, and bioavailability of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where fluorine incorporation enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Light-Emitting Diodes (OLEDs): Acts as a building block for electron-transport or emissive layer materials in OLED devices.
• Chemical Research & Development: A versatile reagent for studying structure-activity relationships (SAR) and for introducing the difluorocinnamoyl moiety into complex molecules.
• Peptide Mimetics: Incorporated into peptide analogs to enhance stability against enzymatic degradation.

Basic Information

Product Name	trans-2,3-Difluorocinnamic Acid
CAS No.	236746-13-7
Molecular Formula	C9H6F2O2
Molecular Weight	184.14 g/mol
Synonyms	(E)-3-(2,3-Difluorophenyl)acrylic acid; (2E)-3-(2,3-Difluorophenyl)prop-2-enoic acid; 2,3-Difluorocinnamic Acid, trans-; trans-3-(2,3-Difluorophenyl)acrylic Acid; (E)-2,3-Difluorocinnamic Acid; 236746-13-7; 2,3-DFCA
EINECS	Contact for details

Quality Control

Our trans-2,3-Difluorocinnamic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere for long-term storage to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.