Description

2,7-Diaza-Spiro[4.4]Nonane-2-Carboxylic Acid tert-Butyl Ester is a sophisticated, nitrogen-containing spirocyclic building block of significant interest in advanced organic synthesis. Its rigid, three-dimensional structure and protected carboxylic acid functionality make it a high-value intermediate for constructing complex molecular architectures. This compound is primarily utilized by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, including protease inhibitors and other biologically relevant molecules.

Application

• Pharmaceutical Intermediate: A key chiral scaffold in the synthesis of drug candidates targeting various diseases.
• Protease Inhibitor Development: Used to construct core structures for inhibitors of enzymes like HCV NS3/4A protease.
• Agrochemical Research: Serves as a building block for novel herbicides and pesticides with specific modes of action.
• Chemical Biology & Medicinal Chemistry: Employed in fragment-based drug discovery and library synthesis due to its sp3-rich character.
• Peptidomimetics: Integral for creating conformationally restricted peptide analogs to enhance stability and bioavailability.
• Ligand Synthesis for Catalysis: Used in the preparation of novel chiral ligands for asymmetric catalysis.

Basic Information

Product Name	2,7-Diaza-Spiro[4.4]Nonane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	236406-49-8
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	2,7-Diaza-spiro[4.4]nonane-2-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 2,7-diaza-spiro[4.4]nonane-2-carboxylate; 2,7-Diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester; 2-tert-Butoxycarbonyl-2,7-diaza-spiro[4.4]nonane; BOC-2,7-Diaza-spiro[4.4]nonane; 2-(tert-Butoxycarbonyl)-2,7-diazaspiro[4.4]nonane
EINECS	Contact for details

Quality Control

Our 2,7-Diaza-Spiro[4.4]Nonane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.