Description

(1S,3S)-3-(Benzyloxy)Cyclobutan-1-Ol CAS NO 233276-35-2 is a high-purity, stereochemically defined chiral building block featuring a cyclobutane core functionalized with a benzyl-protected alcohol. This compound matters as a critical synthetic intermediate for constructing complex molecules with precise three-dimensional architecture, enabling the development of novel active pharmaceutical ingredients (APIs) and advanced materials. Pharmaceutical researchers and fine chemical manufacturers need it for applications in asymmetric synthesis, medicinal chemistry, and the production of high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for small molecule drugs.
• Asymmetric Synthesis: Used as a building block to introduce the cyclobutane moiety with defined stereochemistry into more complex molecular frameworks.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship studies to explore the impact of the rigid cyclobutane structure on biological activity.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate in the optimization and commercial-scale production of APIs.
• Fine Chemical Synthesis: Utilized in the synthesis of specialty chemicals, ligands for catalysis, and advanced organic materials.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	(1S,3S)-3-(Benzyloxy)Cyclobutan-1-Ol
CAS No.	233276-35-2
Molecular Formula	C11H14O2
Molecular Weight	178.23 g/mol
Synonyms	(1S,3S)-3-(Phenylmethoxy)cyclobutan-1-ol; (1s,3s)-3-(Benzyloxy)cyclobutan-1-ol; rel-(1S,3S)-3-(Benzyloxy)cyclobutan-1-ol; 3-Benzyloxycyclobutan-1-ol (stereoisomer); Cyclobutan-1-ol, 3-(benzyloxy)-, (1S,3S)-; (1S,3S)-3-(Benzyloxy)-1-cyclobutanol; Benzyl (1S,3S)-3-hydroxycyclobutyl ether
EINECS	Contact for details

Quality Control

Our (1S,3S)-3-(Benzyloxy)Cyclobutan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from techniques including HPLC, GC, NMR, and optical rotation to confirm identity, assay, and enantiomeric/excess. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.