Description

Benzyl-Peg6-Thp CAS NO 230620-74-3 is a specialized polyethylene glycol (PEG) derivative featuring a benzyl group and a tetrahydropyran (THP) protecting group, connected by a hexaethylene glycol spacer. This bifunctional linker is critical for constructing complex molecular architectures, offering controlled reactivity and solubility in both organic and aqueous media. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as prodrug synthesis, bioconjugation, and polymer chemistry.

Application

• Pharmaceutical Linker: A key intermediate in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Prodrug Development: Used to create cleavable PEGylated prodrugs for enhanced drug solubility and controlled release.
• Bioconjugation Chemistry: Facilitates the attachment of drugs, dyes, or other functional molecules to proteins, peptides, or surfaces.
• Polymer Modification: Serves as a functional initiator or monomer for synthesizing tailored, amphiphilic block copolymers.
• Material Science: Employed in the surface functionalization of nanoparticles and biomaterials to improve biocompatibility and targeting.
• Chemical Biology Tool: Used in the development of probes and reagents for studying biological processes and interactions.

Basic Information

Product Name	Benzyl-Peg6-Thp
CAS No.	230620-74-3
Molecular Formula	C30H52O9
Molecular Weight	556.73 g/mol
Synonyms	1-Benzyloxy-3,6,9,12,15,18-hexaoxahenicosan-21-yl Tetrahydropyran-2-yl Ether; Benzyl-PEG6-THP; Benzyl Hexaethylene Glycol THP Ether; Benzyl-O-(CH2CH2O)6-THP; THP-PEG6-O-Benzyl; 2-(2-{2-[2-(2-{2-[(Tetrahydropyran-2-yl)oxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl Benzyl Ether; Benzyl-PEG6-tetrahydropyranyl ether
EINECS	Contact for details

Quality Control

Our Benzyl-Peg6-Thp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.