Description

1,4,7,10-Tetraazacyclododecane-1,4-Diacetic Acid is a high-purity, functionalized macrocyclic chelating agent, a key intermediate in the synthesis of advanced contrast agents and radiopharmaceuticals. Its core value lies in its ability to form exceptionally stable complexes with a variety of metal ions, including gadolinium and lutetium, which is critical for medical imaging and targeted radiotherapy. This product is essential for manufacturers and research institutions in the pharmaceutical, diagnostic imaging, and nuclear medicine sectors who require reliable, high-quality building blocks for their development pipelines.

Application

• Pharmaceutical Intermediate: Primary building block for synthesizing Gadolinium-based MRI contrast agents (e.g., derivatives of Gadoteridol).
• Radiopharmaceuticals: Chelator precursor for labeling with therapeutic radioisotopes like Lutetium-177 or diagnostic isotopes like Gallium-68 for targeted cancer therapy and PET imaging.
• Research & Development: Used in academic and industrial R&D for developing new metal complexes for catalysis, sensing, and material science.
• Diagnostic Agent Synthesis: Key starting material for producing high-relaxivity contrast agents used in magnetic resonance imaging (MRI).
• Coordination Chemistry: Serves as a model ligand in studies of macrocyclic complex stability and kinetics.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4-Diacetic Acid
CAS No.	229312-34-9
Molecular Formula	C14H26N4O4
Molecular Weight	314.38 g/mol
Synonyms	DO2A; 1,4,7,10-Tetraazacyclododecane-1,4-diacetic acid; 1,4-Diacetic Acid-1,4,7,10-Tetraazacyclododecane; 1,4,7,10-Tetraazacyclododecane-N,N'-diacetic Acid; DO2A chelator; Cyclen-1,4-diacetic Acid; 1,4-Bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane; 2,2'-(1,4,7,10-Tetraazacyclododecane-1,4-diyl)diacetic acid
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,4-Diacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards suitable for pharmaceutical intermediate applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.