Description

7,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid Ethyl Ester is a high-purity fluorinated quinoline derivative that serves as a critical synthetic intermediate in advanced pharmaceutical research and development. Its value lies in its unique molecular scaffold, which is essential for constructing complex molecules with targeted biological activity. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antibiotic and antibacterial agents, particularly fluoroquinolone derivatives.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the bioactivity of the quinoline core.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, enabling the creation of complex chemical libraries for screening.
• Material Science: Investigated as a potential component in the development of organic electronic materials and fluorescent markers.
• Academic & Contract Research: Employed in university and CRO laboratories for medicinal chemistry programs and structure-activity relationship (SAR) studies.

Basic Information

Product Name	7,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	228728-81-2
Molecular Formula	C₁₂H₉F₂NO₃
Molecular Weight	253.20 g/mol
Synonyms	Ethyl 7,8-Difluoro-4-hydroxyquinoline-3-carboxylate; 4-Hydroxy-7,8-difluoroquinoline-3-carboxylic Acid Ethyl Ester; 7,8-Difluoro-4-hydroxy-3-quinolinecarboxylic Acid Ethyl Ester; 3-Quinolinecarboxylic acid, 7,8-difluoro-4-hydroxy-, ethyl ester; Ethyl 7,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
EINECS	Contact for details

Quality Control

Our 7,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.