Description

7,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid CAS NO 228728-17-4 is a high-purity fluorinated quinoline derivative that serves as a critical advanced pharmaceutical intermediate. Its value lies in its unique molecular scaffold, which is essential for synthesizing novel, potent active pharmaceutical ingredients (APIs) with enhanced biological activity and metabolic stability. This compound is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antibacterial and anticancer therapeutics.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel fluoroquinolone antibiotics and other bioactive molecules.
• Antibacterial Drug Research: Used in medicinal chemistry programs to develop new compounds targeting DNA gyrase and topoisomerase IV.
• Oncology Research: Serves as a precursor for developing targeted cancer therapies and kinase inhibitors.
• Chemical Synthesis: Utilized in organic synthesis for introducing the difluoroquinoline core into more complex molecular architectures.
• Agrochemical Development: Potential intermediate in the research and development of new crop protection agents.
• Material Science Research: Investigated for creating novel organic electronic materials or fluorescent probes due to its quinoline structure.

Basic Information

Product Name	7,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid
CAS No.	228728-17-4
Molecular Formula	C10H5F2NO3
Molecular Weight	225.15 g/mol
Synonyms	4-Hydroxy-7,8-difluoroquinoline-3-carboxylic acid; 7,8-Difluoro-4-hydroxy-3-quinolinecarboxylic acid; 3-Quinolinecarboxylic acid, 7,8-difluoro-4-hydroxy-; 7,8-Difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 228728-17-4; Difluoro hydroxyquinoline carboxylic acid
EINECS	Contact for details

Quality Control

Our 7,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.