Description

3-Quinolinecarboxylic Acid, 6-Bromo-8-Fluoro-4-Hydroxy-, Ethyl Ester is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its complex molecular architecture, featuring bromo, fluoro, and hydroxy substituents on the quinoline core, makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and specialty fine chemicals. This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors seeking to incorporate sophisticated quinoline motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly in oncology and anti-infective research, leveraging its halogenated quinoline scaffold.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, where the fluorine and bromine atoms can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Employed in the creation of novel metal-organic complexes and catalysts for asymmetric synthesis and other specialized chemical transformations.
• Material Science Precursor: Acts as a building block for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge-transport materials, due to the quinoline's electron-transport properties.
• Fluorescent Probe Synthesis: Utilized in the design and synthesis of fluorescent dyes and molecular probes for bio-imaging and diagnostic applications.
• Academic & Contract Research: A valuable reagent for medicinal chemistry programs and structure-activity relationship (SAR) studies in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 6-Bromo-8-Fluoro-4-Hydroxy-, Ethyl Ester
CAS No.	228728-06-1
Molecular Formula	C₁₂H₉BrFNO₃
Molecular Weight	314.11 g/mol
Synonyms	Ethyl 6-Bromo-8-fluoro-4-hydroxyquinoline-3-carboxylate; 6-Bromo-8-fluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester; 4-Hydroxy-6-bromo-8-fluoroquinoline-3-carboxylic Acid Ethyl Ester; 3-Carbethoxy-6-bromo-8-fluoro-4-hydroxyquinoline; Quinoline-3-carboxylic acid, 6-bromo-8-fluoro-4-hydroxy-, ethyl ester; 228728-06-1; 6-Br-8-F-4-OH-Q-3-COOEt
EINECS	Contact for details

Quality Control

Our production of 3-Quinolinecarboxylic Acid, 6-Bromo-8-Fluoro-4-Hydroxy-, Ethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.