Description

Chloro[(S)-(-)-2,2'-Bis(Di-p-Tolylphosphino)-1,1'-Binaphthyl](p-Cymene)Ruthenium(II) Chloride is a high-value, chiral ruthenium complex widely recognized as a highly efficient and enantioselective catalyst. This compound matters for its exceptional performance in facilitating asymmetric hydrogenation and other key synthetic transformations, enabling the production of optically pure intermediates. It is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for the development of chiral active pharmaceutical ingredients (APIs) and specialty molecules.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical synthesis.
• Pharmaceutical Intermediate Production: Key in manufacturing chiral building blocks for APIs targeting central nervous system, cardiovascular, and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Manufacturing: Enables the synthesis of high-value chiral compounds for flavors, fragrances, and advanced materials.
• Academic and Industrial R&D: A vital tool for methodological development in organic synthesis and catalysis research.
• Process Chemistry Optimization: Employed for scaling up enantioselective reactions from laboratory to pilot plant and production scale.

Basic Information

Product Name	Chloro[(S)-(-)-2,2'-Bis(Di-p-Tolylphosphino)-1,1'-Binaphthyl](p-Cymene)Ruthenium(II) Chloride
CAS No.	228120-95-4
Molecular Formula	C61H52Cl2P2Ru
Molecular Weight	1010.92 g/mol
Synonyms	(S)-(-)-RuCl(p-cymene)[BINAP]; (S)-RuCl(p-cymene)(BINAP)Cl; (S)-BINAP-Ru(p-cymene)Cl2; (S)-Ru(BINAP)(p-cymene)Cl2; Dichloro[(S)-(-)-2,2'-bis(di-p-tolylphosphino)-1,1'-binaphthyl](p-cymene)ruthenium(II); (S)-BINAP-Ru(II)(p-cymene) dichloride; RuCl2[(S)-BINAP](p-cymene); (S)-RuCl2(p-cymene)(BINAP)
EINECS	Contact for details

Quality Control

Our Chloro[(S)-(-)-2,2'-Bis(Di-p-Tolylphosphino)-1,1'-Binaphthyl](p-Cymene)Ruthenium(II) Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis, to ensure it meets the high standards required for catalytic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. This material is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Keep the container sealed in a cool, dry, and well-ventilated place away from incompatible materials.

Specification

Item	Specification
Appearance	Reddish-brown to brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Solubility	Soluble in dichloromethane, toluene; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.