Description

Phospholane, 1-Hydroxy-2,5-Diphenyl-, 1-Oxide, (2R,5R)- is a high-value, stereochemically defined organophosphorus compound, specifically the (2R,5R) enantiomer. This compound serves as a crucial chiral ligand precursor or catalyst in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily required by R&D laboratories, pharmaceutical intermediates manufacturers, and advanced chemical synthesis facilities focused on developing novel therapeutic agents and high-performance materials.

Application

• Asymmetric Catalysis: As a chiral ligand or ligand precursor in transition metal-catalyzed reactions such as hydrogenation, hydroformylation, and cross-coupling.
• Pharmaceutical Intermediate Synthesis: For the enantioselective construction of complex molecules in the development of active pharmaceutical ingredients (APIs).
• Advanced Material Research: In the synthesis of chiral polymers or materials with specific optical properties.
• Academic & Industrial R&D: As a key reagent for methodological development in organic and organometallic chemistry.
• Agrochemical Synthesis: Potential use in creating enantiomerically pure pesticides or plant growth regulators.

Basic Information

Product Name	Phospholane, 1-Hydroxy-2,5-Diphenyl-, 1-Oxide, (2R,5R)-
CAS No.	226393-33-5
Molecular Formula	C17H17O2P
Molecular Weight	284.29 g/mol
Synonyms	(2R,5R)-1-Hydroxy-2,5-diphenylphospholane 1-oxide; (R,R)-1-Hydroxy-2,5-diphenylphospholane 1-oxide; (2R,5R)-2,5-Diphenyl-1-hydroxyphospholane 1-oxide; (R,R)-HDPPO; Chiral hydroxyphospholane oxide; (R,R)-1-Hydroxy-2,5-diphenylphospholane P-oxide; 1-Hydroxy-2,5-diphenylphospholane 1-oxide, (R,R)-; (2R,5R)-(-)-1-Hydroxy-2,5-diphenylphospholane 1-oxide
EINECS	Contact for details

Quality Control

Our (2R,5R)-1-Hydroxy-2,5-diphenylphospholane 1-oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (enantiomeric excess) determination by HPLC, to ensure compliance with stringent R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, purity, and chiral assay are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 98.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.