Description

(S)-Biphenyl-4-Yl-tert-Butoxycarbonylamino-Acetic Acid CAS NO 225517-19-1 is a high-purity, non-natural amino acid derivative featuring a chiral center and a biphenyl moiety. This compound is a critical chiral building block for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutics, particularly in areas requiring specific stereochemistry and enhanced molecular recognition.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially protease inhibitors and receptor antagonists.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a sterically hindered, aromatic amino acid analog into peptide chains.
• Chemical Biology & Proteomics: Serves as a building block for creating specialized probes, inhibitors, or labeled compounds to study enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity for medicinal chemistry programs.
• API Development: Integral in the synthetic route for potential Active Pharmaceutical Ingredients (APIs) targeting central nervous system (CNS) disorders, inflammation, and oncology.

Basic Information

Product Name	(S)-Biphenyl-4-Yl-tert-Butoxycarbonylamino-Acetic Acid
CAS No.	225517-19-1
Molecular Formula	C21H23NO4
Molecular Weight	353.41 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-2-(4-phenylphenyl)acetic acid; (S)-Boc-4-Biphenylglycine; (S)-N-Boc-4-Biphenylglycine; (S)-2-(Boc-amino)-2-(biphenyl-4-yl)acetic acid; Biphenyl-4-yl-N-Boc-glycine (S-enantiomer); (S)-α-((tert-Butoxycarbonyl)amino)-4-phenylbenzenacetic acid; (S)-Boc-Bphg-OH; 225517-19-1
EINECS	Contact for details

Quality Control

Our (S)-Biphenyl-4-Yl-tert-Butoxycarbonylamino-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and standard pharmacopeial identification tests. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical characteristics to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.