Description

3-o-(4-Methoxybenzyl)-4-C-Hydroxymethyl-1,2-o-Isopropylidine-α-D-Ribofuranose is a high-purity, protected ribofuranose derivative, a critical chiral building block in advanced organic synthesis. Its value lies in providing a chemically defined scaffold for the precise construction of complex nucleoside analogs and other bioactive molecules. This product is essential for research and development laboratories, pharmaceutical intermediates manufacturers, and fine chemical producers focused on antiviral, anticancer, and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer drug discovery.
• Antiviral Pro-drug Development: Used in the research and production of protected intermediates for pro-drugs targeting viruses like HCV, HIV, and SARS-CoV-2.
• Oligonucleotide Synthesis: Serves as a protected monomer or building block for the solid-phase synthesis of modified oligonucleotides and antisense agents.
• Glycochemistry & Glycobiology: Acts as a versatile intermediate for the synthesis of complex carbohydrates, glycoconjugates, and glycomimetics.
• Chemical Biology Research: Employed in the development of molecular probes, labeled nucleotides, and tools for studying enzymatic mechanisms.
• Process Chemistry & Scale-up: Suitable for use in process development and cGMP manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3-o-(4-Methoxybenzyl)-4-C-Hydroxymethyl-1,2-o-Isopropylidine-α-D-Ribofuranose
CAS No.	225233-47-6
Molecular Formula	C17H24O6
Molecular Weight	324.37 g/mol
Synonyms	1,2-O-Isopropylidene-3-O-(4-methoxybenzyl)-4-C-(hydroxymethyl)-α-D-ribofuranose; 4-C-Hydroxymethyl-1,2-O-isopropylidene-3-O-(4-methoxybenzyl)-α-D-ribofuranose; 3-O-p-Methoxybenzyl-4-C-hydroxymethyl-1,2-O-isopropylidene-α-D-ribofuranose; PMB-Protected Ribofuranose Derivative; 4-C-Hydroxymethyl Ribofuranose PMB Ether; 1,2-O-Isopropylidene-3-O-(p-methoxybenzyl)-α-D-ribofuranose-4-C-methanol; α-D-Ribofuranose, 3-O-(4-methoxybenzyl)-4-C-(hydroxymethyl)-1,2-O-(1-methylethylidene)-
EINECS	Contact for details

Quality Control

Our 3-o-(4-Methoxybenzyl)-4-C-Hydroxymethyl-1,2-o-Isopropylidine-α-D-Ribofuranose is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.