Description

1-(4-Nitrophenyl)Piperidine-3-Carboxylic Acid is a high-purity, functionalized piperidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its unique molecular structure, which incorporates both a carboxylic acid and a nitrophenyl group, making it a versatile intermediate for constructing complex pharmacophores. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting the central nervous system (CNS) or requiring piperidine-based scaffolds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides where the nitrophenyl moiety can impart specific biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating complex ligands used in asymmetric catalysis or metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to develop molecular probes for studying enzyme function or receptor interactions due to its modifiable functional groups.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in medicinal chemistry and novel synthetic route exploration.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of specialty chemicals, dyes, and advanced materials.

Basic Information

Product Name	1-(4-Nitrophenyl)Piperidine-3-Carboxylic Acid
CAS No.	223786-53-6
Molecular Formula	C12H14N2O4
Molecular Weight	250.25 g/mol
Synonyms	3-Piperidinecarboxylic acid, 1-(4-nitrophenyl)-; 1-(4-Nitrophenyl)nipecotic acid; Nipecotic acid, 1-(4-nitrophenyl)-; 1-(p-Nitrophenyl)piperidine-3-carboxylic acid; 1-(4-Nitrophenyl)-3-piperidinecarboxylic acid; 223786-53-6; 1-(4-Nitrophenyl)nipecotate
EINECS	Contact for details

Quality Control

Our production of 1-(4-Nitrophenyl)Piperidine-3-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support cGMP (current Good Manufacturing Practice) compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.