Description

(1S,2S)-2-Fluorocyclopentan-1-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its stereochemically defined fluorinated cyclopentane scaffold, which is crucial for modulating the biological activity and metabolic stability of drug candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics, particularly in areas requiring conformationally constrained, fluorinated amine motifs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Research: Serves as a precursor for developing novel fluorinated pesticides and herbicides, where the fluorine atom can enhance bioavailability and environmental persistence.
• Medicinal Chemistry: Used extensively in structure-activity relationship (SAR) studies and lead optimization to introduce fluorine and amine functional groups into candidate molecules.
• Asymmetric Synthesis: Employed as a chiral auxiliary or resolving agent in stereoselective synthetic routes due to its defined (1S,2S) configuration.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms and receptor-ligand interactions where a fluorinated, rigid backbone is advantageous.
• Peptidomimetics: Used in the design of peptide mimics where the cyclopentane ring replaces traditional amino acid backbones to improve metabolic stability.

Basic Information

Product Name	(1S,2S)-2-Fluorocyclopentan-1-Amine Hydrochloride
CAS No.	223756-94-3
Molecular Formula	C5H11ClFN
Molecular Weight	139.60 g/mol
Synonyms	(1S,2S)-2-Fluorocyclopentanamine hydrochloride; (1S,2S)-2-Fluorocyclopentylamine hydrochloride; trans-2-Fluorocyclopentan-1-amine hydrochloride; (1S,2S)-1-Amino-2-fluorocyclopentane hydrochloride; 2-Fluorocyclopentanamine hydrochloride, (1S,2S)-; (1S,2S)-2-Fluoro-1-cyclopentanamine hydrochloride; trans-2-Fluorocyclopentylamine HCl
EINECS	Contact for details

Quality Control

Our (1S,2S)-2-Fluorocyclopentan-1-Amine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data including chiral purity and impurity profiling. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and related substances are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Maximum Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.