Description

n-Alloc-Ethylenediamine Hydrochloride is a protected derivative of ethylenediamine, featuring an allyloxycarbonyl (Alloc) protecting group on one nitrogen atom. This compound is a critical building block in organic synthesis, particularly in peptide chemistry and medicinal chemistry, where it enables the selective modification and sequential assembly of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic agents, and advanced materials.

Application

• Peptide Synthesis: Serves as a key intermediate for introducing a selectively deprotectable ethylenediamine spacer or linker into peptide chains.
• Medicinal Chemistry & Drug Discovery: Used in the synthesis of targeted drug candidates, including antibody-drug conjugates (ADCs) and small molecule inhibitors.
• Bioconjugation: Acts as a versatile linker for coupling bioactive molecules, fluorophores, or other functional groups to proteins, antibodies, or nanoparticles.
• Solid-Phase Synthesis: An essential reagent for Fmoc/t-Bu and Alloc-based solid-phase peptide synthesis (SPPS) strategies.
• Polymer Chemistry: Employed in the creation of functionalized polymers and dendrimers with amine-reactive sites.
• Chemical Biology Probes: Facilitates the development of probes for studying enzyme activity and biomolecular interactions.

Basic Information

Product Name	n-Alloc-Ethylenediamine Hydrochloride
CAS No.	223741-66-0
Molecular Formula	C6H13ClN2O2
Molecular Weight	180.63 g/mol
Synonyms	N-Alloc-Ethylenediamine Hydrochloride; N-(2-Aminoethyl)-N-[(allyloxy)carbonyl]amine Hydrochloride; 2-[(Allyloxycarbonyl)amino]ethylamine Hydrochloride; Alloc-EDA·HCl; Nα-Alloc-ethylenediamine hydrochloride; Allyl N-(2-aminoethyl)carbamate hydrochloride; (2-Aminoethyl)carbamic acid allyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our n-Alloc-Ethylenediamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided and available upon request, supporting compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.