Description

5,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid is a high-purity, fluorinated quinoline derivative serving as a critical advanced pharmaceutical intermediate. Its core value lies in its unique molecular scaffold, which is essential for synthesizing novel active pharmaceutical ingredients (APIs) with enhanced biological activity and metabolic stability. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of next-generation therapeutics, particularly in the areas of anti-infectives and oncology.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel fluoroquinolone antibiotics and other bioactive molecules.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex heterocyclic compounds and studying structure-activity relationships (SAR).
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation pesticides and herbicides.
• Material Science: Potential monomer or additive in the development of specialty polymers and advanced organic electronic materials.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical testing laboratories.

Basic Information

Product Name	5,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid
CAS No.	223690-44-6
Molecular Formula	C10H5F2NO3
Molecular Weight	225.15 g/mol
Synonyms	4-Hydroxy-5,8-difluoroquinoline-3-carboxylic acid; 5,8-Difluoro-4-hydroxy-3-quinolinecarboxylic acid; 3-Quinolinecarboxylic acid, 5,8-difluoro-4-hydroxy-; 5,8-Difluoro-4-hydroxyquinoline-3-carboxylate; DFHQCA
EINECS	Contact for details

Quality Control

Our 5,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.