Description

5,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid Ethyl Ester is a high-value fluorinated quinoline derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in its unique molecular scaffold, which is essential for constructing complex molecules with tailored biological and photophysical properties. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antibacterial and antiviral agents, leveraging the bioactive quinoline core.
• Agrochemical Research: Used in developing next-generation fungicides and herbicides, where the difluoro and hydroxy groups modulate activity and selectivity.
• Material Science Precursor: Serves as a starting material for creating organic semiconductors, fluorescent dyes, and metal-chelating ligands.
• Chemical Synthesis: Versatile intermediate for further functionalization, including hydrolysis to the corresponding acid or reactions at the ester and hydroxy groups.
• Academic & R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	5,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	223690-43-5
Molecular Formula	C₁₂H₉F₂NO₃
Molecular Weight	253.20 g/mol
Synonyms	Ethyl 5,8-Difluoro-4-hydroxyquinoline-3-carboxylate; 4-Hydroxy-5,8-difluoroquinoline-3-carboxylic Acid Ethyl Ester; 3-Quinolinecarboxylic acid, 5,8-difluoro-4-hydroxy-, ethyl ester; 5,8-Difluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester; Ethyl 5,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
EINECS	Contact for details

Quality Control

Our 5,8-Difluoro-4-Hydroxyquinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.