Description

(S)-1-(Phenylsulfonyl)Pipecolinic Acid is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its core value proposition lies in providing a stereochemically defined piperidine scaffold, which is crucial for developing bioactive molecules with precise pharmacological profiles. This compound is essential for research chemists and process development teams in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients requiring specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new chemical entities (NCEs), especially in central nervous system (CNS) and antiviral drug discovery programs.
• Chiral Ligand/ Catalyst Precursor: Serves as a starting material for synthesizing sophisticated chiral ligands used in asymmetric catalysis.
• Agrochemical Synthesis: Used in the development of advanced, stereoselective pesticides and herbicides where the (S)-configuration is critical for activity.
• Peptidomimetics Research: The pipecolinic acid moiety is a common proline surrogate in the design of peptide analogs with enhanced metabolic stability.
• Chemical Biology Probe Development: Employed as a scaffold for creating tool compounds to study enzyme function and biological pathways.
• Process Chemistry & Scale-up: Used in route scouting and optimization for the commercial-scale production of target APIs.

Basic Information

Product Name	(S)-1-(Phenylsulfonyl)Pipecolinic Acid
CAS No.	223562-03-6
Molecular Formula	C12H15NO4S
Molecular Weight	269.32 g/mol
Synonyms	(S)-1-(Benzenesulfonyl)pipecolinic acid; (S)-1-(Phenylsulfonyl)piperidine-2-carboxylic acid; (2S)-1-(Phenylsulfonyl)piperidine-2-carboxylic acid; (S)-1-(Phenylsulfonyl)-2-piperidinecarboxylic acid; (S)-N-(Phenylsulfonyl)pipecolic Acid; (S)-PS-Pip-OH; L-1-(Phenylsulfonyl)pipecolinic Acid
EINECS	Contact for details

Quality Control

Our (S)-1-(Phenylsulfonyl)Pipecolinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.