Description

2-Azaspiro[4.4]Nonan-3-One,7-Methyl-,(7R)-(9Ci) is a high-purity, chiral spirocyclic lactam building block of significant interest in advanced organic synthesis. Its rigid, three-dimensional structure makes it a valuable scaffold for constructing complex molecules with defined stereochemistry. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients. The specific stereochemistry, indicated by the (7R) designation, is critical for its intended biological and chemical interactions.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of lead compounds.
• Agrochemical Synthesis: Employed in the research and development of new pesticides and herbicides, where its spirocyclic structure can contribute to unique modes of action.
• Catalyst and Ligand Development: Acts as a precursor for sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Item	Details
Product Name	2-Azaspiro[4.4]Nonan-3-One,7-Methyl-,(7R)-(9Ci)
CAS No.	223425-68-1
Molecular Formula	C9H15NO
Molecular Weight	153.22 g/mol
Synonyms	(7R)-7-Methyl-2-azaspiro[4.4]nonan-3-one; (7R)-7-Methyl-2-azaspiro[4.4]nonan-3-one (9CI); 2-Azaspiro[4.4]nonan-3-one, 7-methyl-, (7R)-; (R)-7-Methyl-2-azaspiro[4.4]nonan-3-one; 7-Methyl-2-azaspiro[4.4]nonan-3-one, (R)-; Chiral Spirocyclic Lactam; 7-Methyl-2-azaspiro[4.4]nonan-3-one (enantiomer)
EINECS	Contact for details

Quality Control

Our 2-Azaspiro[4.4]Nonan-3-One,7-Methyl-,(7R)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.