Description

1-Bromo-5-(1,3-Dioxolan-2-Yl)-2-Methoxybenzene is a high-value, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound matters for its role as a key intermediate in the synthesis of complex molecules, offering a protected aldehyde functionality and a versatile halogen handle for cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a benzaldehyde or benzoic acid derivative framework.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactive bromine and protected aldehyde groups.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine or nitrogen-based ligands used in homogeneous catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional polymers where precise aromatic architecture is required.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Academic & Contract Research: A valuable reagent for methodological development and exploring new synthetic pathways in academic and industrial research laboratories.

Basic Information

Product Name	1-Bromo-5-(1,3-Dioxolan-2-Yl)-2-Methoxybenzene
CAS No.	223418-72-2
Molecular Formula	C10H11BrO3
Molecular Weight	259.10 g/mol
Synonyms	2-Bromo-4-(1,3-dioxolan-2-yl)-1-methoxybenzene; 5-Bromo-2-methoxybenzaldehyde ethylene acetal; 2-Methoxy-5-(1,3-dioxolan-2-yl)phenyl bromide; (5-Bromo-2-methoxyphenyl)(1,3-dioxolan-2-yl)methane; 1-Bromo-5-(1,3-dioxolan-2-yl)-2-methoxy-benzene; 2-(5-Bromo-2-methoxyphenyl)-1,3-dioxolane
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-(1,3-Dioxolan-2-Yl)-2-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in cGMP environments, and we can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be kept under an inert atmosphere for long-term storage to maximize shelf life. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.