Description

Ruthenium, Dichloro[1,3-Dihydro-1,3-Bis(2,4,6-Trimethylphenyl)-2H-Imidazol-2-Ylidene](Phenylmethylene)(Tricyclohexylphosphine)-, (Sp-5-41)- is a highly specialized, second-generation Grubbs-Hoveyda type olefin metathesis catalyst. This compound matters for enabling efficient, selective, and robust carbon-carbon double bond formation under mild conditions, a cornerstone reaction in advanced organic synthesis. It is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty polymer industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Key for ring-closing metathesis (RCM) and cross-metathesis (CM) in the production of active pharmaceutical ingredients (APIs) and complex heterocycles.
• Agrochemical Development: Used to construct novel, bioactive macrocyclic and olefinic compounds for crop protection agents.
• Specialty Polymer & Material Science: Enables the synthesis of precision polymers via acyclic diene metathesis (ADMET) polymerization and the creation of functionalized materials.
• Fine Chemical & Fragrance Manufacturing: Facilitates the efficient and selective synthesis of olefinic intermediates for flavors, fragrances, and other high-value chemicals.
• Academic & Industrial R&D: An essential tool for methodological development in organic synthesis and catalysis research.
• Cross-Coupling & Tandem Catalysis: Can be employed in sequential or tandem catalytic processes with other transition metal catalysts for complex molecule assembly.

Basic Information

Product Name	Ruthenium, Dichloro[1,3-Dihydro-1,3-Bis(2,4,6-Trimethylphenyl)-2H-Imidazol-2-Ylidene](Phenylmethylene)(Tricyclohexylphosphine)-, (Sp-5-41)-
CAS No.	223415-64-3
Molecular Formula	C46H63Cl2N2PRu
Molecular Weight	848.94 g/mol
Synonyms	Grubbs-Hoveyda II Catalyst; Hoveyda-Grubbs Catalyst 2nd Generation; (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium; Dichloro(o-isopropoxyphenylmethylene)(1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)ruthenium(II); HG II; RuCl2(IMesH2)(CH-2-OiPrC6H4); [RuCl2(H2IMes)(CH-2-(OiPr)C6H4)]
EINECS	Contact for details

Quality Control

Our Ruthenium, Dichloro[1,3-Dihydro-1,3-Bis(2,4,6-Trimethylphenyl)-2H-Imidazol-2-Ylidene](Phenylmethylene)(Tricyclohexylphosphine)-, (Sp-5-41)- is manufactured under stringent quality systems. Each batch undergoes rigorous analytical testing, including NMR and elemental analysis, to ensure high catalytic activity and purity. Comprehensive Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided to guarantee reproducible performance in your critical metathesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. This material is moisture-sensitive (hygroscopic) and easily oxidized; ensure containers are sealed immediately after use.

Specification

Item	Specification
Appearance	Purple to brown crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Elemental Analysis (C, H, N)	Within theoretical ± 0.4%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.