Description

Methyl (1S,3R)-3-Aminocyclohexane-1-Carboxylate Hydrochloride is a high-purity, stereochemically defined chiral building block essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder therapeutics. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in enantioselective synthesis and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates, especially in neurology and psychiatry.
• Asymmetric Synthesis: Used as a precursor in catalytic asymmetric reactions to construct stereogenic centers with high enantiomeric purity.
• Peptidomimetics Research: Serves as a constrained amino acid analog in the design and development of novel peptide-based therapeutics.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization programs.
• Process R&D: Scalable intermediate for the development of robust and cost-effective commercial manufacturing routes for APIs.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	Methyl (1S,3R)-3-Aminocyclohexane-1-Carboxylate Hydrochloride
CAS No.	222530-35-0
Molecular Formula	C8H16ClNO2
Molecular Weight	193.67 g/mol
Synonyms	(1S,3R)-Methyl 3-aminocyclohexanecarboxylate hydrochloride; (1S,3R)-3-Amino-1-cyclohexanecarboxylic acid methyl ester hydrochloride; Methyl trans-3-aminocyclohexanecarboxylate hydrochloride (isomer); Methyl 3-aminocyclohexanecarboxylate HCl; trans-Methyl 3-aminocyclohexanecarboxylate hydrochloride; (1S,3R)-3-Aminocyclohexane-1-carboxylic acid methyl ester hydrochloride; Chiral cyclohexane amino ester hydrochloride; CAS 222530-35-0
EINECS	Contact for details

Quality Control

Our Methyl (1S,3R)-3-Aminocyclohexane-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.