Description

Fmoc-2-(2-Aminoethoxy)-Ethylamine Hydrochloride is a high-purity, protected amine derivative essential for advanced organic synthesis and peptide chemistry. This compound serves as a critical building block for introducing functionalized linker arms, enabling the creation of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic agents, and sophisticated bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a versatile Fmoc-protected diamine linker for the introduction of polyethylene glycol (PEG)-like spacers into peptide sequences.
• Bioconjugation & Probe Development: For the site-specific attachment of fluorescent dyes, affinity tags (e.g., biotin), or drug molecules to proteins, antibodies, or other biomolecules.
• Dendrimer and Polymer Synthesis: Acts as a functional branching unit or monomer for constructing well-defined dendritic structures and functional polymers.
• Chemical Biology Research: Used in the synthesis of activity-based probes (ABPs) and other tools for studying enzyme function and protein-protein interactions.
• Drug Discovery & Medicinal Chemistry: Employed to create linker-drug intermediates for Antibody-Drug Conjugates (ADCs) and other targeted delivery systems.
• Material Science Functionalization: For the surface modification of nanoparticles, resins, and other materials to introduce amine-reactive groups.

Basic Information

Product Name	Fmoc-2-(2-Aminoethoxy)-Ethylamine Hydrochloride
CAS No.	221352-88-1
Molecular Formula	C21H27N2O4Cl
Molecular Weight	406.90 g/mol
Synonyms	Fmoc-NH-(CH2)2-O-(CH2)2-NH2·HCl; Nα-Fmoc-2,2'-(ethylenedioxy)diethylamine hydrochloride; 2-[2-(Fmoc-amino)ethoxy]ethylamine hydrochloride; Fmoc-AEEA-amine hydrochloride; N-(9-Fluorenylmethoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine hydrochloride; Fmoc-8-amino-3,6-dioxaoctylamine hydrochloride; Fmoc-dPEG®2-amine hydrochloride
EINECS	Contact for details

Quality Control

Our Fmoc-2-(2-Aminoethoxy)-Ethylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.