Description

4-(Fmoc-Amino)Piperidine Hydrochloride is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of the piperidine moiety while protecting the amine functionality. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential assembly of complex peptides, where the Fmoc group provides orthogonal protection.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of potential drug candidates, particularly those targeting GPCRs or requiring constrained scaffolds.
• Peptidomimetic Design: Incorporates the piperidine structure to mimic peptide backbones, improving metabolic stability and bioavailability of lead compounds.
• Combinatorial Chemistry Libraries: Serves as a versatile building block for generating diverse compound libraries for high-throughput screening.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling of peptides or proteins for diagnostic and biochemical studies.

Basic Information

Product Name	4-(Fmoc-Amino)Piperidine Hydrochloride
CAS No.	221352-86-9
Molecular Formula	C₂₁H₂₅ClN₂O₂
Molecular Weight	372.89 g/mol
Synonyms	1-Fmoc-4-aminopiperidine hydrochloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-aminopiperidine hydrochloride; 4-[(9-Fluorenylmethyloxycarbonyl)amino]piperidine hydrochloride; 4-(Fmoc-amino)piperidine HCl; Fmoc-4-Ampi·HCl; 4-Amino-1-Fmoc-piperidine hydrochloride; N-Fmoc-4-aminopiperidine hydrochloride; Piperidine, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 4-(Fmoc-Amino)Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for water content, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.