Description

Quinoline, 8-[(4S)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]- is a high-value, chiral oxazoline-substituted quinoline derivative, identified by CAS No. 220629-00-5. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile chiral ligand or catalyst precursor in asymmetric synthesis. It is essential for R&D and production teams in the pharmaceutical, agrochemical, and fine chemical sectors who require high-purity, structurally complex building blocks for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Asymmetric Catalysis: Serves as a precursor for chiral oxazoline ligands used in metal-catalyzed asymmetric reactions (e.g., hydrogenation, cyclopropanation).
• Agrochemical Synthesis: Intermediate in the development of advanced, enantiomerically pure pesticides and herbicides.
• Material Science Research: Used in the development of functional organic materials and metal-organic frameworks (MOFs) due to its complex chelating structure.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and process chemistry optimization.

Basic Information

Product Name	Quinoline, 8-[(4S)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-
CAS No.	220629-00-5
Molecular Formula	C16H20N2O
Molecular Weight	256.35 g/mol
Synonyms	(4S)-4-tert-Butyl-2-(quinolin-8-yl)-4,5-dihydrooxazole; 8-[(4S)-4-(tert-Butyl)-4,5-dihydro-1,3-oxazol-2-yl]quinoline; (S)-4-tert-Butyl-2-(8-quinolyl)-2-oxazoline; (S)-8-(4-tert-Butyl-4,5-dihydrooxazol-2-yl)quinoline; Chiral Oxazoline-Quinoline Ligand Precursor; Quinoline-oxazoline derivative; tert-Butyl Oxazoline Quinoline; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, GC, and 1H/13C NMR to confirm identity, enantiomeric excess (ee), and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.