Description

(S)-4-Phenyl-2-(Quinolin-8-Yl)-4,5-Dihydrooxazole is a high-value chiral oxazoline ligand and a key synthetic intermediate in asymmetric catalysis. Its precise stereochemistry and rigid molecular framework make it indispensable for constructing complex, enantiomerically pure molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing novel active ingredients and advanced materials.

Application

• As a chiral ligand in asymmetric synthesis, including hydrogenation, cyclopropanation, and Diels-Alder reactions.
• A critical building block for the synthesis of novel pharmaceutical candidates and agrochemicals.
• Used in academic and industrial R&D to explore new catalytic systems and reaction methodologies.
• Employed in the preparation of functional materials and specialty polymers requiring specific chiral environments.
• Acts as a precursor for the synthesis of more complex N,O-bidentate ligands and organocatalysts.

Basic Information

Product Name	(S)-4-Phenyl-2-(Quinolin-8-Yl)-4,5-Dihydrooxazole
CAS No.	220628-99-9
Molecular Formula	C18H14N2O
Molecular Weight	274.32 g/mol
Synonyms	(S)-(-)-4-Phenyl-2-(8-quinolyl)-2-oxazoline; (S)-4-Phenyl-2-(8-quinolinyl)-4,5-dihydrooxazole; (S)-2-(Quinolin-8-yl)-4-phenyl-4,5-dihydrooxazole; (S)-PQO; (S)-8-Quinolyl-4-phenyl-2-oxazoline; (S)-2-(8-Quinolyl)-4-phenyl-2-oxazoline; (S)-4-Phenyl-2-(8-quinolyl)-4,5-dihydrooxazole
EINECS	Contact for details

Quality Control

We supply (S)-4-Phenyl-2-(Quinolin-8-Yl)-4,5-Dihydrooxazole in high-purity grades suitable for demanding research and process development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing chiral purity, chemical purity, and identity are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.