Description

Quinoline, 8-[(4S)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]- is a specialized chiral oxazoline-substituted quinoline derivative, serving as a high-value building block in advanced organic synthesis. Its core value lies in its ability to act as a versatile ligand precursor and a key intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and catalytic systems.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of potential drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Asymmetric Catalysis Ligand: Serves as a precursor for developing novel chiral oxazoline ligands used in transition metal-catalyzed asymmetric reactions (e.g., hydrogenation, cyclopropanation).
• Agrochemical Research: Intermediate in the development of new-generation, stereoselective pesticides and herbicides.
• Material Science: Used in the synthesis of functionalized organic molecules for advanced materials, such as organic light-emitting diodes (OLEDs) or liquid crystals.
• Academic & Contract Research: Critical reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural products and other high-value specialty chemicals.

Basic Information

Product Name	Quinoline, 8-[(4S)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]-
CAS No.	220628-98-8
Molecular Formula	C15H16N2O
Molecular Weight	240.30 g/mol
Synonyms	(4S)-4-Isopropyl-2-(quinolin-8-yl)-4,5-dihydrooxazole; 8-[(4S)-4,5-Dihydro-4-(1-Methylethyl)-2-oxazolyl]quinoline; (S)-4-Isopropyl-2-(8-quinolyl)-2-oxazoline; (S)-8-(4-Isopropyl-4,5-dihydrooxazol-2-yl)quinoline; Chiral Oxazoline-Quinoline Ligand Precursor; (S)-Quinox; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our production of Quinoline, 8-[(4S)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized by HPLC, chiral analysis, NMR, and mass spectrometry to confirm identity, enantiomeric excess (ee), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO 9001 compliant manufacturing for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to prevent degradation. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.