Description

trans-2-(3-Chloro-4-Methylphenyl)Cyclopropane-1-Carboxylic Acid is a high-value, synthetically derived cyclopropane carboxylic acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique sterically constrained cyclopropane ring fused with a substituted aromatic system makes it an essential intermediate for constructing complex molecular architectures with specific spatial orientations. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the cyclopropane moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized chiral ligands and organocatalysts used in asymmetric synthesis to control stereochemistry.
• Material Science Research: Investigated as a monomer or additive for creating polymers with unique thermal and mechanical properties due to the rigid cyclopropane structure.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	trans-2-(3-Chloro-4-Methylphenyl)Cyclopropane-1-Carboxylic Acid
CAS No.	220353-93-5
Molecular Formula	C11H11ClO2
Molecular Weight	210.66 g/mol
Synonyms	(1R,2S)-2-(3-Chloro-4-methylphenyl)cyclopropanecarboxylic acid; (1S,2R)-2-(3-Chloro-4-methylphenyl)cyclopropanecarboxylic acid; trans-2-(3-Chloro-p-tolyl)cyclopropanecarboxylic Acid; 2-(3-Chloro-4-methylphenyl)cyclopropanecarboxylic acid; 3-Chloro-4-methyl-trans-cinnamic acid cyclopropane derivative; (3-Chloro-4-methylphenyl)cyclopropanecarboxylic acid; CCRIS 9379; AOB67717
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. We adhere to strict in-process controls and final release specifications. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are available upon request. Our quality management system supports cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.