Description

4-(((tert-Butoxycarbonyl)Amino)Methyl)Bicyclo[2.2.2]Octane-1-Carboxylicacid is a high-purity, advanced pharmaceutical intermediate featuring a unique, rigid bicyclo[2.2.2]octane scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates where structural rigidity and defined stereochemistry are required. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers specializing in complex, small-molecule APIs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex active pharmaceutical ingredients (APIs) targeting neurological and metabolic disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce conformational restraint and improve pharmacokinetic properties of lead compounds.
• Peptidomimetic Synthesis: Serves as a constrained, non-natural amino acid analog in the development of novel peptide-based therapeutics.
• Ligand Development: Employed in creating specialized ligands for catalysis or receptor binding studies due to its three-dimensional structure.
• Advanced Material Science: Potential monomer or cross-linker for creating polymers with specific thermal and mechanical properties.
• Academic & Industrial R&D: Fundamental research tool in organic synthesis and chemical biology for exploring new molecular architectures.

Basic Information

Product Name	4-(((tert-Butoxycarbonyl)Amino)Methyl)Bicyclo[2.2.2]Octane-1-Carboxylicacid
CAS No.	219996-49-3
Molecular Formula	C16H27NO4
Molecular Weight	297.39 g/mol
Synonyms	1-Boc-aminomethylbicyclo[2.2.2]octane-4-carboxylic acid; 4-((((1,1-Dimethylethoxy)carbonyl)amino)methyl)bicyclo[2.2.2]octane-1-carboxylic acid; 4-(((Boc)Amino)Methyl)Bicyclo[2.2.2]Octane-1-Carboxylic Acid; 4-(Boc-aminomethyl)bicyclo[2.2.2]octane-1-carboxylic acid; Bicyclo[2.2.2]octane-1-carboxylic acid, 4-(((1,1-dimethylethoxy)carbonyl)amino)methyl]-; 4-((tert-Butoxycarbonylamino)methyl)adamantane-1-carboxylic acid (common misnomer based on structure); t-BOC-AMBCA; 219996-49-3
EINECS	Contact for details

Quality Control

Our 4-(((tert-Butoxycarbonyl)Amino)Methyl)Bicyclo[2.2.2]Octane-1-Carboxylicacid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our production adheres to cGMP guidelines suitable for pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.