Description

Methyl 4-Chloro-5,8-Difluoro-Quinoline-2-Carboxylate is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its role as a key intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists working on novel active ingredients, including antibacterial quinolones and other fluorinated bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel fluoroquinolone antibiotics and other drug candidates targeting bacterial infections.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides and herbicides, leveraging the biological activity of the quinoline core.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials, ligands for catalysts, or fluorescent dyes due to its conjugated quinoline structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of targeted, high-value compounds under cGMP conditions where applicable.

Basic Information

Product Name	Methyl 4-Chloro-5,8-Difluoro-Quinoline-2-Carboxylate
CAS No.	219949-93-6
Molecular Formula	C₁₁H₆ClF₂NO₂
Molecular Weight	257.62 g/mol
Synonyms	Methyl 4-chloro-5,8-difluoro-2-quinolinecarboxylate; 4-Chloro-5,8-difluoroquinoline-2-carboxylic acid methyl ester; 2-Quinolinecarboxylic acid, 4-chloro-5,8-difluoro-, methyl ester; 219949-93-6; Methyl 4-chloro-5,8-difluoroquinoline-2-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 4-Chloro-5,8-Difluoro-Quinoline-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high standards, from R&D to scale-up under ISO or cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.