Description

Fmoc-2-Aminomethyl-Benzoic Acid is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of ortho-aminomethylbenzoic acid residues into peptide chains, enabling the creation of complex molecular architectures. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise assembly of custom peptide sequences.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Incorporation into non-natural peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Bioconjugation and Probe Development: Used to introduce specific functional handles or fluorescent tags into biomolecules for diagnostic and imaging applications.
• Combinatorial Chemistry Libraries: Serves as a versatile scaffold in the generation of diverse compound libraries for high-throughput screening.
• Academic Research: Fundamental studies in organic chemistry, biochemistry, and medicinal chemistry exploring structure-activity relationships.

Basic Information

Product Name	Fmoc-2-Aminomethyl-Benzoic Acid
CAS No.	219640-94-5
Molecular Formula	C24H21NO4
Molecular Weight	387.43 g/mol
Synonyms	Fmoc-AMB-OH; 2-(((9H-Fluoren-9-yl)methoxy)carbonyl)aminomethyl)benzoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(aminomethyl)benzoic Acid; Fmoc-2-(Aminomethyl)benzoic Acid; N-Fmoc-2-aminomethylbenzoic Acid; 2-(Fmoc-aminomethyl)benzoic Acid; 2-[(Fmoc-amino)methyl]benzoic Acid; 2-[[(9-Fluorenylmethoxycarbonyl)amino]methyl]benzoic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-2-Aminomethyl-Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.