Description

H-Thr(Tbu)-Allyl Ester Hcl is a protected amino acid derivative, specifically an O-tert-butyl threonine allyl ester hydrochloride salt. This compound is a crucial building block in the synthesis of complex peptides and pharmaceutical intermediates, offering orthogonal protection strategies for carboxyl and hydroxyl groups. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for advanced drug discovery and development projects.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of threonine residues with protected side chains.
• Solution-Phase Peptide Chemistry: Used in the synthesis of complex peptide sequences and cyclic peptides where selective deprotection is required.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of novel therapeutic peptides and peptidomimetics.
• Bioconjugation: The allyl ester protecting group can be utilized in selective conjugation strategies for creating peptide-drug conjugates or labeled biomolecules.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial Research: A valuable reagent for methodological development in organic synthesis and peptide science.

Basic Information

Product Name	H-Thr(Tbu)-Allyl Ester Hcl
CAS No.	218938-63-7
Molecular Formula	C12H24ClNO4
Molecular Weight	281.78 g/mol
Synonyms	H-Thr(O-tBu)-OAllyl·HCl; O-tert-Butyl-L-threonine allyl ester hydrochloride; L-Threonine, O-(1,1-dimethylethyl)-, allyl ester, hydrochloride (1:1); Allyl O-(tert-butyl)-L-threoninate hydrochloride; Fmoc-Thr(tBu)-OH allyl ester precursor; Protected Threonine Allyl Ester HCl; Thr(tBu)-OAllyl·HCl; Peptide Synthesis Building Block 218938-63-7
EINECS	Contact for details

Quality Control

Our H-Thr(Tbu)-Allyl Ester Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure compliance with high-purity standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.