Description

1-Bromo-2-(2,2,2-trifluoroethoxy)benzene is a high-purity, specialty fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its unique combination of a bromo substituent and a trifluoroethoxy side chain, which introduces both reactivity and lipophilicity into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, as well as by manufacturers of liquid crystals and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery and development, particularly for candidates targeting the central nervous system or requiring metabolic stability.
• Agrochemical Active Ingredient Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoroethoxy group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a foundational component for creating fluorinated aromatic cores in electronic display and lighting materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions to introduce functionalized aromatic rings.
• Chemical Research & Development: Utilized in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel fluorinated compounds.

Basic Information

Product Name	1-Bromo-2-(2,2,2-trifluoroethoxy)benzene
CAS No.	218610-57-2
Molecular Formula	C8H6BrF3O
Molecular Weight	255.03 g/mol
Synonyms	2-Bromo-1-(2,2,2-trifluoroethoxy)benzene; o-Bromophenyl 2,2,2-trifluoroethyl ether; 1-Bromo-2-(2,2,2-trifluoroethoxy)benzene; 2-(2,2,2-Trifluoroethoxy)bromobenzene; Benzene, 1-bromo-2-(2,2,2-trifluoroethoxy)-; 2-Bromo-alpha,alpha,α-trifluorophenetole
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(2,2,2-trifluoroethoxy)benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures material consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.