Description

Boc-(R)-3-Amino-4-(2-Fluoro-Phenyl)-Butyric Acid is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a fluorinated aromatic side chain. This compound is a critical chiral building block for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other targeted therapeutics. It is essential for research and production in pharmaceutical, biotechnology, and advanced organic synthesis sectors requiring precise stereochemistry and fluorinated motifs to modulate bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and GMP-scale production of novel drug candidates, especially protease inhibitors and enzyme-targeted therapies.
• Peptide Synthesis: Serves as a protected fluorinated amino acid residue in solid-phase and solution-phase peptide synthesis for creating specialized peptide libraries and bioactive peptides.
• Chemical Biology & Proteomics: Used in the design and synthesis of activity-based probes, enzyme substrates, and inhibitors for studying enzyme mechanisms and protein interactions.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to introduce fluorine atoms and chiral centers into lead compounds, optimizing their potency, selectivity, and pharmacokinetic properties.
• API Development: Integral to the synthetic route of fluorinated active pharmaceutical ingredients, contributing to enhanced drug efficacy and patent life.

Basic Information

Product Name	Boc-(R)-3-Amino-4-(2-Fluoro-Phenyl)-Butyric Acid
CAS No.	218608-98-1
Molecular Formula	C15H20FNO4
Molecular Weight	297.32 g/mol
Synonyms	(R)-3-[(tert-Butoxycarbonyl)amino]-4-(2-fluorophenyl)butanoic acid; (R)-3-(Boc-Amino)-4-(2-fluorophenyl)butyric acid; Boc-D-3-Amino-4-(2-fluorophenyl)butyric acid; (R)-Boc-3-Amino-4-(2-fluoro-phenyl)-butanoic acid; N-Boc-3-amino-4-(2-fluorophenyl)butanoic acid; (R)-N-Boc-3-Amino-4-(2-fluorophenyl)butyric Acid; tert-Butyl (R)-(1-carboxy-3-(2-fluorophenyl)propyl)carbamate; 218608-98-1
EINECS	Contact for details

Quality Control

Our Boc-(R)-3-Amino-4-(2-Fluoro-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D and production. Certificates of Analysis (COA) documenting identity, purity, enantiomeric excess, and impurity profiles are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.