Description

Ethyl 4,7-Dichloro-6-Fluoroquinoline-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. It is essential for research and development chemists, process scale-up engineers, and manufacturers in the global pharmaceutical and fine chemical industries who require reliable, high-quality raw materials for their synthesis pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of novel fluoroquinolone antibacterial agents.
• API Synthesis: Used in the research and commercial manufacturing of active pharmaceutical ingredients (APIs) targeting bacterial infections.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new therapeutic candidates.
• Fine Chemical Production: Employed in multi-step organic synthesis to introduce the complex quinoline core structure into target molecules.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for cGMP-compliant production of drug substances.
• Academic & Industrial R&D: Utilized in laboratories for developing new synthetic methodologies and exploring new chemical entities.

Basic Information

Product Name	Ethyl 4,7-Dichloro-6-Fluoroquinoline-3-Carboxylate
CAS No.	218457-57-9
Molecular Formula	C₁₂H₈Cl₂FNO₂
Molecular Weight	288.10 g/mol
Synonyms	Ethyl 4,7-dichloro-6-fluoroquinoline-3-carboxylate; 4,7-Dichloro-6-fluoroquinoline-3-carboxylic acid ethyl ester; 6-Fluoro-4,7-dichloroquinoline-3-carboxylic acid ethyl ester; 3-Quinolinecarboxylic acid, 4,7-dichloro-6-fluoro-, ethyl ester; Ethyl 6-fluoro-4,7-dichloroquinoline-3-carboxylate; 218457-57-9; CAS 218457-57-9
EINECS	Contact for details

Quality Control

Our Ethyl 4,7-Dichloro-6-Fluoroquinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.