Description

2-Azabicyclo[2.1.1]Hexane-2-Carboxylic acid, Ethyl ester (9Ci) is a specialized bicyclic organic compound featuring a constrained, bridged azabicyclo[2.1.1]hexane scaffold. This unique structure makes it a valuable advanced pharmaceutical intermediate and a critical building block in medicinal chemistry for the synthesis of novel drug candidates. It is primarily utilized by research institutions and pharmaceutical R&D departments focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in the design and development of new drug molecules, particularly those targeting the central nervous system.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in constructing linkers or warheads for targeted protein degradation platforms.
• Agrochemical Synthesis: Potential intermediate in the creation of novel pesticides and herbicides with specific activity profiles.
• Ligand and Catalyst Development: Utilized in the preparation of novel chiral ligands for asymmetric catalysis.
• Academic and Industrial R&D: Fundamental research chemical for exploring new chemical spaces and reaction methodologies.

Basic Information

Product Name	2-Azabicyclo[2.1.1]Hexane-2-Carboxylic acid, Ethyl ester (9Ci)
CAS No.	217093-76-0
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	Ethyl 2-azabicyclo[2.1.1]hexane-2-carboxylate; 2-Azabicyclo[2.1.1]hexane-2-carboxylic acid ethyl ester; 2-Carbethoxy-2-azabicyclo[2.1.1]hexane; 1-Aza-3-ethyl bicyclo[2.1.1]hexane-1-carboxylate; 2-Ethoxycarbonyl-2-azabicyclo[2.1.1]hexane; 2-Azabicyclo[2.1.1]hexane-2-carboxylic acid, ethyl ester; 2-Azabicyclo[2.1.1]hexane-2-carboxylate ethyl ester
EINECS	Contact for details

Quality Control

Our 2-Azabicyclo[2.1.1]Hexane-2-Carboxylic acid, Ethyl ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and traceability for your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.