Description

2,4(1H,3H)-Pyrimidinedione, 5-[5-o-[(1,1-Dimethylethyl)Diphenylsilyl]-β-D-Ribofuranosyl]- is a sophisticated nucleoside derivative, specifically a silyl-protected intermediate of significant value in synthetic organic chemistry. This compound matters as a critical building block for the controlled synthesis of modified nucleosides and oligonucleotides, enabling advanced research and development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antiviral drug discovery, nucleic acid chemistry, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key protected precursor in the multi-step synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA/DNA strands for research, diagnostics, and therapeutic applications (e.g., antisense oligonucleotides, siRNA).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Bioconjugation: The silyl protecting group allows for selective deprotection, facilitating the controlled attachment of other functional molecules or labels.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under GMP-like conditions.
• Academic & Institutional Research: Fundamental studies in nucleic acid chemistry, enzymology, and molecular biology.

Basic Information

Item	Detail
Product Name	2,4(1H,3H)-Pyrimidinedione, 5-[5-o-[(1,1-Dimethylethyl)Diphenylsilyl]-β-D-Ribofuranosyl]-
CAS No.	215110-22-8
Molecular Formula	C25H30N2O6Si
Molecular Weight	482.61 g/mol
Synonyms	5'-O-(tert-Butyldiphenylsilyl)-2'-deoxyuridine; 5'-O-TBDPS-2'-deoxyuridine; TBDPS-protected 2'-deoxyuridine; 1-[(2R,4S,5R)-4-[(tert-Butyldiphenylsilyl)oxy]-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 2'-Deoxy-5'-O-(tert-butyldiphenylsilyl)uridine; 5'-O-(1,1-Dimethylethyl)diphenylsilyl-2'-deoxy-β-D-uridine; Protected deoxyuridine intermediate; Uridine, 2'-deoxy-, 5'-(tert-butyldiphenylsilyl) ether
EINECS	Contact for details

Quality Control

Our 2,4(1H,3H)-Pyrimidinedione, 5-[5-o-[(1,1-Dimethylethyl)Diphenylsilyl]-β-D-Ribofuranosyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance as a critical synthetic intermediate. Standard quality verification includes chromatographic purity analysis and structural confirmation. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.