Description

4-(Fmoc-Hydrazino)-Benzoic Acid CAS NO 214475-53-3 is a high-purity, protected amino acid derivative designed for advanced organic synthesis. This compound is a critical building block for the solid-phase and solution-phase synthesis of complex peptides and other bioactive molecules, offering precise control over molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, proteomics research, and the development of novel therapeutic agents.

Application

• Peptide Synthesis: A key intermediate for the controlled incorporation of hydrazino benzoic acid motifs into peptide chains during Fmoc-based solid-phase peptide synthesis (SPPS).
• Drug Discovery & Medicinal Chemistry: Serves as a versatile scaffold for constructing targeted libraries and modifying pharmacophores to enhance drug-like properties.
• Bioconjugation & Linker Chemistry: Used in the preparation of chemical linkers and cross-linking agents for antibody-drug conjugates (ADCs) and protein labeling.
• Proteomics Research: Employed in the synthesis of activity-based probes (ABPs) and other chemical tools for studying enzyme function and protein interactions.
• Material Science: Acts as a monomer or functionalization agent for creating specialized polymers and surfaces with tailored hydrazine-based reactivity.

Basic Information

Product Name	4-(Fmoc-Hydrazino)-Benzoic Acid
CAS No.	214475-53-3
Molecular Formula	C22H18N2O4
Molecular Weight	374.39 g/mol
Synonyms	Fmoc-Hydrazino-BA; 4-[(9-Fluorenylmethoxycarbonyl)hydrazino]benzoic Acid; Benzoic acid, 4-[(9H-fluoren-9-ylmethoxy)carbonyl]hydrazino]-; 4-(N-Fmoc-hydrazino)benzoic acid; Fmoc-NHNH-Bz-OH; 4-(Fmoc-hydrazino)benzoic acid; Nα-Fmoc-hydrazinobenzoic acid
EINECS	Contact for details

Quality Control

Our 4-(Fmoc-Hydrazino)-Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and an inert atmosphere to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.