Description

4-Chloro-7-(3-Chloro-Propoxy)-6-Methoxy-Quinoline-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex quinoline-based structure. This compound is valued for its role as a critical building block in the synthesis of targeted therapeutic agents, where its specific substitution pattern enables precise molecular modifications. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step production of novel drug candidates and active pharmaceutical ingredients (APIs).
• Oncology Research: Serves as a core scaffold in the research and development of targeted cancer therapies and kinase inhibitors.
• Chemical Synthesis: Used in organic synthesis for the construction of complex heterocyclic compounds and functionalized quinoline derivatives.
• R&D Laboratories: Employed in academic and industrial research for structure-activity relationship (SAR) studies and medicinal chemistry programs.
• Process Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and bespoke molecular entities.

Basic Information

Product Name	4-Chloro-7-(3-Chloro-Propoxy)-6-Methoxy-Quinoline-3-Carbonitrile
CAS No.	214470-68-5
Molecular Formula	C₁₄H₁₂Cl₂N₂O₂
Molecular Weight	311.16 g/mol
Synonyms	4-Chloro-7-(3-chloropropoxy)-6-methoxyquinoline-3-carbonitrile; 6-Methoxy-4-chloro-7-(3-chloropropoxy)quinoline-3-carbonitrile; 3-Quinolinecarbonitrile, 4-chloro-7-(3-chloropropoxy)-6-methoxy-; 214470-68-5; Quinoline-3-carbonitrile, 4-chloro-7-(3-chloropropoxy)-6-methoxy-; 4-Chloro-7-(3-chloropropoxy)-6-methoxy-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-(3-Chloro-Propoxy)-6-Methoxy-Quinoline-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.