Description

D-[1,5-13C2]Ribose is a stable isotope-labeled analog of the essential pentose sugar, D-ribose, specifically enriched with carbon-13 at the 1 and 5 positions. This precise labeling makes it an indispensable tool for advanced metabolic research and analytical method development, providing critical insights into biochemical pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require high-fidelity tracers for NMR spectroscopy, mass spectrometry, and metabolic flux analysis.

Application

• Metabolic Pathway Tracing: Used as a stable isotope tracer in NMR (Nuclear Magnetic Resonance) and LC/MS (Liquid Chromatography/Mass Spectrometry) studies to elucidate nucleotide sugar metabolism and glycosylation pathways.
• Pharmaceutical Research & Development: Critical for the development and validation of bioanalytical methods for drug metabolism and pharmacokinetics (DMPK) studies involving ribose-containing compounds.
• Internal Standard for Quantification: Serves as a high-precision internal standard in mass spectrometry for the accurate quantification of D-ribose and related metabolites in complex biological matrices.
• Biochemical Synthesis: Employed in the synthesis of isotopically labeled nucleotides, nucleosides, and other biomolecules for structural and functional studies.
• Diagnostic Agent Development: Used in research for developing novel Positron Emission Tomography (PET) tracers and other diagnostic imaging agents.

Basic Information

Product Name	D-[1,5-13C2]Ribose
CAS No.	213825-56-0
Molecular Formula	C5H10O5 (with 13C at positions 1 & 5)
Molecular Weight	152.10 g/mol (approx., based on isotopic enrichment)
Synonyms	1,5-13C2-Ribose; D-Ribose-1,5-13C2; [1,5-13C2]-D-Ribose; (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal-1,5-13C2; Isotopically Labeled D-Ribose; 13C2-Ribose; Stable Isotope-Labeled Ribose
EINECS	Contact for details

Quality Control

Every batch of D-[1,5-13C2]Ribose is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including NMR and HPLC-MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, isotopic enrichment, and purity specifications to ensure it meets the exacting requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C (at positions 1 & 5)
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.