Description

3-Fluoro-4-Iodo-Quinoline is a high-value halogenated quinoline derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it an exceptionally versatile intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other heterocyclic-based therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the quinoline scaffold is a common motif for bioactive molecules.
• Material Science: Serves as a building block for creating organic semiconductors, liquid crystals, and fluorescent dyes due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), enabling rapid diversification of the quinoline core.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and enzyme functions.
• Academic & Contract Research: Essential for methodological development in organic chemistry and for custom synthesis projects in contract research organizations (CROs).

Basic Information

Product Name	3-Fluoro-4-Iodo-Quinoline
CAS No.	213772-63-5
Molecular Formula	C9H5FIN
Molecular Weight	273.05 g/mol
Synonyms	4-Iodo-3-fluoroquinoline; Quinoline, 3-fluoro-4-iodo-; 3-Fluoro-4-iodoquinoline; 4-Iodo-3-fluorochinolin; 213772-63-5; 3-F-4-I-Quinoline; 3-Fluoro-4-iodo-chinolin
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-Iodo-Quinoline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profile. Our quality protocols are designed to support regulatory filings in pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent contamination and moisture absorption. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.