Description

Rhodium(1+), [(1,2,5,6-η)-1,5-Cyclooctadiene][(2S,2'S,5S,5'S)-1,1'-(1,2-Ethanediyl)Bis[2,5-Bis(1-Methylethyl)Phospholane-κp]]-, Tetrafluoroborate(1-) (9Ci) is a highly specialized, chiral rhodium(I) complex featuring a DuPhos-type ligand, renowned for its exceptional performance in asymmetric catalysis. This compound is a premium catalyst designed to deliver superior enantioselectivity and high turnover numbers in critical synthetic transformations. It is an essential tool for pharmaceutical R&D and fine chemical synthesis, where precise stereochemical control is paramount for producing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric Hydrogenation: A premier catalyst for the enantioselective hydrogenation of prochiral olefins, enamides, and ketones, crucial for creating single-enantiomer pharmaceutical building blocks.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and scalable production of chiral intermediates for cardiovascular, neurological, and oncological drugs.
• Fine Chemical and Agrochemical Manufacturing: Used in the synthesis of complex, high-value molecules requiring specific stereochemistry for enhanced biological activity.
• Academic and Industrial Research: Serves as a benchmark catalyst in methodological development for new asymmetric reactions and process optimization studies.
• Process Chemistry Development: Employed in pilot plants and scale-up facilities to establish robust, cost-effective manufacturing routes for chiral compounds.

Basic Information

Product Name	Rhodium(1+), [(1,2,5,6-η)-1,5-Cyclooctadiene][(2S,2'S,5S,5'S)-1,1'-(1,2-Ethanediyl)Bis[2,5-Bis(1-Methylethyl)Phospholane-κp]]-, Tetrafluoroborate(1-) (9Ci)
CAS No.	213343-68-1
Molecular Formula	C34H58BF4P2Rh
Molecular Weight	706.45 g/mol
Synonyms	(1,5-Cyclooctadiene)((2S,2'S,5S,5'S)-(-)-2,2'-(1,2-Ethanediyl)bis(2,5-dihydro-2,5-dimethyl-3,4-diisopropylphosphole))rhodium(I) Tetrafluoroborate; Rhodium(I)-(R,R)-1,2-Bis(2,5-diisopropylphospholano)benzene(1,5-cyclooctadiene) Tetrafluoroborate; [Rh((R,R)-DIPAMP)(COD)]BF4 (related analog); DuPhos-Rhodium(I) COD Complex Tetrafluoroborate; Chiral Rhodium DuPhos Catalyst; Asymmetric Hydrogenation Catalyst Rh-DuPhos; Rh((R,R)-i-Pr-DuPhos)(COD)BF4
EINECS	Contact for details

Quality Control

Every batch of our chiral rhodium catalyst is produced and tested under strict quality protocols to ensure consistent, high-performance catalytic activity. We employ advanced analytical techniques including NMR, HPLC, and elemental analysis to verify chemical identity, enantiomeric purity of the ligand, and rhodium content. A comprehensive Certificate of Analysis (COA) detailing assay, chiral purity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (Rhodium Content)	≥ 14.5%
Purity (HPLC)	≥ 98.0%
Solubility	Soluble in dichloromethane, acetone; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.