Description

cis-2-Amino-1-Cyclopentanecarboxylic Acid Hydrochloride Hemihydrate, 99 is a high-purity, non-proteinogenic amino acid derivative, specifically the hydrochloride salt hemihydrate of the cis isomer. This compound is a critical chiral building block for the synthesis of complex pharmaceutical intermediates and bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery, peptide synthesis, and the development of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in neurological and metabolic disorder research.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce constrained, cyclic amino acid motifs that can enhance peptide stability and biological activity.
• Protease & Enzyme Inhibitor Development: Serves as a core structural component in designing potent and selective inhibitors for various enzymes.
• Chemical Biology & Proteomics: Employed as a tool compound or labeled analog for studying biological pathways and protein function.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective organic synthesis to construct complex molecular architectures.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	cis-2-Amino-1-Cyclopentanecarboxylic Acid Hydrochloride Hemihydrate, 99
CAS No.	212755-84-5
Molecular Formula	C6H12ClNO2 • 0.5H2O
Molecular Weight	174.62 g/mol (Anhydrous basis)
Synonyms	(1R,2S)-2-Aminocyclopentanecarboxylic Acid Hydrochloride Hemihydrate; cis-2-Aminocyclopentanecarboxylic Acid HCl Hemihydrate; cis-ACPC HCl Hemihydrate; (1R,2S)-2-Aminocyclopentane-1-carboxylic Acid Hydrochloride Hemihydrate; cis-2-Amino-1-cyclopentanecarboxylic Acid Hydrochloride Monohydrate (common alias); cis-ACPA HCl Hemihydrate
EINECS	Contact for details

Quality Control

Our cis-2-Amino-1-Cyclopentanecarboxylic Acid Hydrochloride Hemihydrate, 99 is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm isomeric identity, and Karl Fischer titration for water content, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 99.0%
Chiral Purity (HPLC)	≥ 99.0% cis isomer
Water Content (KF)	3.5 - 5.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.