Description

[3-Nitro-5-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Phenoxy]Acetaldehyde is a specialized, high-value chemical building block featuring a photoreactive diazirine group and a reactive aldehyde functionality. This compound is critical for advanced research and development, particularly in the field of photoaffinity labeling for studying biomolecular interactions. It is primarily utilized by pharmaceutical R&D laboratories, chemical biology research groups, and specialized fine chemical manufacturers engaged in proteomics and drug discovery.

Application

• Photoaffinity Labeling Probes: Serves as a key photoreactive crosslinker for covalent capture of transient protein-ligand or protein-protein interactions in chemical biology.
• Proteomics Research: Used to synthesize probes for target identification and mapping binding sites of bioactive small molecules.
• Bioconjugation Chemistry: The aldehyde group allows for site-specific conjugation to amines via Schiff base formation, useful for attaching the photoreactive moiety to peptides, proteins, or other biomolecules.
• Pharmaceutical Development: Employed in early-stage drug discovery to elucidate mechanisms of action and off-target effects of candidate drug molecules.
• Material Science Functionalization: Potential use in surface modification and creating photo-crosslinkable polymers or coatings with specific surface properties.

Basic Information

Product Name	[3-Nitro-5-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Phenoxy]Acetaldehyde
CAS No.	212207-96-0
Molecular Formula	C11H6F3N3O4
Molecular Weight	301.18 g/mol
Synonyms	3-Nitro-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxyacetaldehyde; 2-[3-Nitro-5-[3-(trifluoromethyl)diazirin-3-yl]phenoxy]acetaldehyde; 5-(3-(Trifluoromethyl)-3H-diazirin-3-yl)-3-nitrophenoxyacetaldehyde; 3-Nitro-5-(3-(trifluoromethyl)diazirin-3-yl)phenoxyacetaldehyde; Photoaffinity Labeling Aldehyde Reagent; Diazirine Phenoxy Acetaldehyde Derivative; Trifluoromethyl Diazirine Aldehyde
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and high purity, which is essential for sensitive research applications. Quality is verified by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.