Description

(R)-3-(2-(Hydroxymethyl)-2,3-Dihydro-1H-Inden-4-Yloxy)Phenyl 4,4,4-Trifluorobutane-1-Sulfonate is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a key building block for the synthesis of complex, biologically active molecules, particularly those targeting specific enantiomeric pathways. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemistry in their synthetic routes. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency and reliability.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder research.
• Chiral Synthesis: Used in asymmetric synthesis to introduce the (R)-configured indane moiety into target molecules, ensuring high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Development: Potential intermediate in the creation of advanced, enantiomerically pure pesticides and herbicides.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals where specific stereochemistry is required for functionality.
• Process Chemistry & Scale-Up: Suitable for use in route development and optimization from laboratory to pilot plant scale.

Basic Information

Product Name	(R)-3-(2-(Hydroxymethyl)-2,3-Dihydro-1H-Inden-4-Yloxy)Phenyl 4,4,4-Trifluorobutane-1-Sulfonate
CAS No.	212188-60-8
Molecular Formula	C20H19F3O5S
Molecular Weight	428.42 g/mol
Synonyms	4,4,4-Trifluoro-1-butanesulfonic Acid 3-[(2R)-2-(Hydroxymethyl)-2,3-dihydro-1H-inden-4-yl]oxy]phenyl Ester; (R)-3-(2-(Hydroxymethyl)-2,3-Dihydro-1H-Inden-4-Yloxy)Phenyl Trifluorobutanesulfonate; (R)-Indanyloxy Phenyl Trifluorobutylsulfonate; CAS 212188-60-8; Chiral Indane Sulfonate Ester; (R)-Configuration Indane Intermediate; TFBS Ester of (R)-Indanol Derivative
EINECS	Contact for details

Quality Control

Our production of (R)-3-(2-(Hydroxymethyl)-2,3-Dihydro-1H-Inden-4-Yloxy)Phenyl 4,4,4-Trifluorobutane-1-Sulfonate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and purity assessment. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay, chiral purity, and impurity profiles. Our quality systems are designed to support cGMP compliance for pharmaceutical applications, ensuring traceability and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light) as indicated. Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.