Description

8-Azabicyclo[3.2.1]Octan-2-One,8-Methyl-6-Propyl-,(1R,5R)-Rel-(9Ci) is a high-purity, stereochemically defined bicyclic lactam building block of significant interest in advanced organic synthesis. Its unique bridged structure and defined stereochemistry make it a critical intermediate for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily utilized by pharmaceutical R&D and fine chemical organizations engaged in the development of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) targets.
• Advanced Organic Synthesis: Serves as a versatile building block for constructing complex, constrained ring systems found in natural products and bioactive molecules.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to explore novel chemical space.
• Asymmetric Synthesis: The defined (1R,5R) relative stereochemistry provides a chiral template for inducing stereoselectivity in downstream reactions.
• Chemical Biology Probes: Potential use in the synthesis of molecular probes for studying biological pathways and enzyme function.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential drug candidates during clinical development phases.

Basic Information

Product Name	8-Azabicyclo[3.2.1]Octan-2-One,8-Methyl-6-Propyl-,(1R,5R)-Rel-(9Ci)
CAS No.	211517-34-9
Molecular Formula	C11H19NO
Molecular Weight	181.27 g/mol
Synonyms	(1R,5R)-rel-8-Methyl-6-propyl-8-azabicyclo[3.2.1]octan-2-one; 8-Azabicyclo[3.2.1]octan-2-one, 8-methyl-6-propyl-, (1R,5R)-rel-; 8-Methyl-6-propyl-8-azabicyclo[3.2.1]octan-2-one (rel-(1R,5R)-form); Bicyclic lactam intermediate 211517-34-9; Tropane derivative lactam; 6-Propyl-8-methyl-8-azabicyclo[3.2.1]octan-2-one (relative (1R,5R) configuration); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 8-Azabicyclo[3.2.1]octan-2-one derivative is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and chiral analysis, to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed when not in use to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (rel-(1R,5R))
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.