Description

4(1H)-Quinazolinone, 8-Hydroxy-2-[4-(Trifluoromethyl)Phenyl]- (9Ci) is a high-purity, advanced pharmaceutical intermediate belonging to the quinazolinone class of heterocyclic compounds. Its molecular structure, featuring a trifluoromethylphenyl substituent, makes it a critical building block for medicinal chemistry research and the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily sought by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates targeting various diseases.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Kinase Inhibitor Development: Serves as a building block for compounds designed to inhibit specific kinase enzymes, relevant in oncology and inflammatory disease research.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to create complex molecules for biological testing.
• Reference Standard: Used as an analytical standard in quality control and method development for API manufacturing.

Basic Information

Item	Details
Product Name	4(1H)-Quinazolinone, 8-Hydroxy-2-[4-(Trifluoromethyl)Phenyl]- (9Ci)
CAS No.	211172-84-8
Molecular Formula	C15H9F3N2O2
Molecular Weight	306.24 g/mol
Synonyms	8-Hydroxy-2-[4-(trifluoromethyl)phenyl]-4(1H)-quinazolinone; 2-(4-Trifluoromethylphenyl)-8-hydroxy-1H-quinazolin-4-one; 8-Hydroxy-2-(4-trifluoromethylphenyl)-4(1H)-quinazolinone; 211172-84-8; 8-Hydroxy-2-(α,α,α-trifluoro-p-tolyl)-4(1H)-quinazolinone
EINECS	Contact for details

Quality Control

Every batch of our 4(1H)-Quinazolinone derivative is produced and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency, which is essential for reliable research and development outcomes. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.