Description

Fmoc-Nh(Ch2)3Nh2 Hcl is a specialized Fmoc-protected diamine building block, essential for solid-phase peptide synthesis (SPPS). Its bifunctional structure, featuring a primary amine and an Fmoc-protected secondary amine, provides critical orthogonality for constructing complex peptide architectures and bioconjugates. This high-purity intermediate is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for introducing a diaminoalkyl linker or spacer within peptide sequences.
• Peptidomimetic Design: Used to create non-natural peptide backbones and constrained structures for enhanced stability and bioactivity.
• Bioconjugation and Linker Chemistry: Serves as a versatile heterobifunctional crosslinker for attaching peptides to other molecules, surfaces, or carriers.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.
• Dendrimer and Polymer Synthesis: Acts as a branching unit or functional monomer in the construction of dendritic and polymeric materials.
• Fluorescent Probe Development: The Fmoc group can be utilized for purification and detection, or cleaved to attach other fluorophores.

Basic Information

Product Name	Fmoc-Nh(Ch2)3Nh2 Hcl
CAS No.	210767-37-6
Molecular Formula	C₂₀H₂₅ClN₂O₂
Molecular Weight	360.88 g/mol
Synonyms	Fmoc-3,3'-Diaminopropylamine Hydrochloride; Nα-Fmoc-Nω-aminopropyl-1,3-diaminopropane Dihydrochloride; 1,3-Diaminopropane, N1-[(9H-fluoren-9-ylmethoxy)carbonyl]-, hydrochloride (1:?); Fmoc-Dap-OH? HCl; N-Fmoc-1,3-diaminopropane hydrochloride; Fmoc-3-Amino-1-propylamine HCl; Fmoc-Dap(NH2)-OH HCl
EINECS	Contact for details

Quality Control

Our Fmoc-Nh(Ch2)3Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.