Description

o-tert-Butyldimethylsilyl 11,12-Didehydro Retinol is a chemically modified derivative of retinol, specifically protected at the hydroxyl group with an o-tert-butyldimethylsilyl (TBDMS) group and featuring a didehydro modification at the 11,12-position. This compound is a crucial advanced pharmaceutical intermediate and a versatile building block in synthetic organic chemistry, offering enhanced stability for complex synthetic manipulations. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for the development and production of novel retinoid-based therapeutics and bioactive molecules.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and production of novel retinoid drugs and analogs targeting dermatological conditions, oncology, and other therapeutic areas.
• Biochemical Research: Used as a stabilized retinol derivative in studies of vitamin A metabolism, cell differentiation, and gene regulation.
• Organic Synthesis: Serves as a protected, advanced building block for the total synthesis of complex natural products and specialized retinoids.
• Cosmeceutical R&D: Employed in the development of high-stability, next-generation anti-aging and skin-repair active ingredients.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical laboratories.

Basic Information

Product Name	o-tert-Butyldimethylsilyl 11,12-Didehydro Retinol
CAS No.	210700-51-9
Molecular Formula	C31H52O2Si
Molecular Weight	484.84 g/mol
Synonyms	11,12-Didehydroretinyl tert-Butyldimethylsilyl Ether; (3E,5E,7E,9E,11E,13E)-3,7,12,16-Tetramethyl-1-[2,6,6-trimethyl-4-(tert-butyldimethylsilyloxy)cyclohex-1-en-1-yl]hexadeca-1,3,5,7,9,11,13,15-octaen-3-ol (TBDMS Ether); TBDMS-11,12-didehydroretinol; o-TBDMS Didehydroretinol; Retinol, 11,12-didehydro-, tert-butyldimethylsilyl ether; Vitamin A derivative, TBDMS protected.
EINECS	Contact for details

Quality Control

Our o-tert-Butyldimethylsilyl 11,12-Didehydro Retinol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets high-grade specifications suitable for research and pharmaceutical applications. Certificates of Analysis (COA) detailing all test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange viscous oil or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.